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Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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Related Experiment Video

Updated: Jun 17, 2026

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

Making circadian cancer therapy practical.

Keith I Block1, Penny B Block, Susan Reynolds Fox

  • 1Block Center for Integrative Cancer Treatment, Evanston, IL 60201, USA. drblock@blockmedical.com

Integrative Cancer Therapies
|January 1, 2010
PubMed
Summary
This summary is machine-generated.

Circadian therapy, including lifestyle changes and timed treatments, can improve cancer patient survival and reduce chemotherapy side effects. Optimizing circadian rhythms is key for better quality of life and outcomes.

More Related Videos

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

Related Experiment Videos

Last Updated: Jun 17, 2026

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

Area of Science:

  • Oncology
  • Chronobiology
  • Integrative Medicine

Background:

  • Circadian rhythms significantly influence cancer patient outcomes and treatment tolerance.
  • Disruptions in circadian functioning are linked to inflammation, stress, and poor sleep, impacting cancer progression.
  • Lifestyle factors and biochemical milieu play crucial roles in maintaining circadian health.

Purpose of the Study:

  • To explore the multifaceted approach of circadian therapy for cancer patients.
  • To investigate the impact of lifestyle interventions on circadian functioning and survival.
  • To evaluate the safety and efficacy of chronomodulated chemotherapy in reducing treatment toxicities.

Main Methods:

  • Reviewing lifestyle interventions: diet, physical activity, and mind-body therapies.
  • Addressing biochemical disruptions: inflammation and stress hormones.
  • Presenting a case series of chronomodulated chemotherapy administration.

Main Results:

  • Improved rest-activity rhythms correlate with better survival in colorectal cancer patients.
  • Chronomodulated chemotherapy significantly reduced severe toxicities (grade 3-4) in 12 cancer patients.
  • Lifestyle and biochemical interventions support normal circadian cycles and reduce sleep disruption.

Conclusions:

  • Integrating lifestyle optimization, biochemical regulation, and chronomodulated treatments offers a comprehensive approach to cancer care.
  • Circadian therapy has the potential to enhance patient quality of life and improve disease outcomes.
  • Timing of treatment is a critical factor in managing chemotherapy-induced toxicities.