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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Hyper-responsive phenotype in localized aggressive periodontitis
L Shaddox1, J Wiedey, E Bimstein
1Department of Periodontology, University of Florida, Gainesville, 32608, USA.
Journal of Dental Research
|January 1, 2010
Summary
Individuals with aggressive periodontitis exhibit a hyper-responsive immune trait, showing increased inflammatory responses. Healthy siblings displayed a less pronounced hyper-inflammatory response to bacterial stimulation.
Area of Science:
- Immunology
- Periodontology
- Oral Health
Background:
- The 'hyper-responsive' trait signifies an amplified inflammatory reaction to innate immune receptor stimulation.
- Aggressive periodontitis (LAgP) is a severe form of gum disease characterized by rapid destruction of periodontal tissues.
Purpose of the Study:
- To investigate the presence of a hyper-reactive immune trait in patients diagnosed with LAgP.
- To compare the immune response of LAgP patients with healthy unrelated individuals and their healthy siblings.
Main Methods:
- Peripheral blood samples were collected from LAgP patients and control groups.
- Blood samples were stimulated with lipopolysaccharide (LPS) from E. coli and P. gingivalis.
- Cytokine and chemokine profiles were analyzed using ANOVA.
Main Results:
- LAgP patient cultures showed elevated pro-inflammatory cytokine/chemokine levels upon LPS stimulation compared to healthy controls.
- Healthy siblings exhibited attenuated hyper-inflammatory profiles.
- Regression analysis linked the hyper-reactive trait to pro-inflammatory mediator expression and lack of anti-inflammatory mediators.
Conclusions:
- A hyper-responsive immune trait is demonstrated in the LAgP cohort.
- Healthy siblings of LAgP patients show attenuated hyper-responsiveness.
- This hyper-responsiveness can be triggered by stimulation of multiple Toll-like receptors (TLRs).
