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Imaging Flow Cytometry to Study Microbial Autoaggregation
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Published on: September 29, 2023

Specific Lactobacillus/Mutans Streptococcus co-aggregation.

C Lang1, M Böttner, C Holz

  • 1ORGANOBALANCE GmbH, Berlin, Germany. lang@organobalance.de

Journal of Dental Research
|January 1, 2010
PubMed
Summary
This summary is machine-generated.

Researchers identified specific probiotic lactobacilli strains that selectively co-aggregate with mutans streptococci, offering a potential method to target harmful oral bacteria without disrupting beneficial ones.

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Purification of a High Molecular Mass Protein in Streptococcus mutans
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Purification of a High Molecular Mass Protein in Streptococcus mutans

Published on: September 14, 2019

Area of Science:

  • Oral microbiology
  • Probiotics
  • Dental caries research

Background:

  • Mutans streptococci are key pathogens in dental caries.
  • Disrupting oral flora to remove mutans streptococci can negatively impact oral health.
  • Targeted removal of mutans streptococci is desirable.

Purpose of the Study:

  • To identify probiotic lactobacilli strains capable of specific in vitro co-aggregation with mutans streptococci.
  • To ensure these lactobacilli do not co-aggregate with other oral commensal bacteria.

Main Methods:

  • Screened 624 lactobacilli strains from a large culture library.
  • Assessed co-aggregation with mutans streptococci and other oral plaque commensals.
  • Characterized the co-aggregation properties of selected strains.

Main Results:

  • Identified 6 lactobacilli strains (L. paracasei or L. rhamnosus) exhibiting specific co-aggregation with mutans streptococci.
  • This specific co-aggregation was heat and protease resistant, calcium-dependent, and functional across a wide pH range.
  • Co-aggregation was unaffected by whole saliva and sugar substitutes.

Conclusions:

  • Novel probiotic lactobacilli strains demonstrate specific co-aggregation with mutans streptococci.
  • These properties suggest a potential strategy for in vivo modulation of oral plaque biofilm.
  • This approach may offer a targeted method to reduce mutans streptococci and prevent dental caries.