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Updated: Jun 17, 2026

Selective Viral Transduction of Adult-born Olfactory Neurons for Chronic in vivo Optogenetic Stimulation
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Selective Viral Transduction of Adult-born Olfactory Neurons for Chronic in vivo Optogenetic Stimulation

Published on: December 28, 2011

A novel method for olfactory bulbectomy using photochemically induced lesion.

Hye-Min Kang1, Jizi Jin, Seungjoo Lee

  • 1Department of Anatomy and Neurobiology, Biomedical Science Institute, School of Medicine, Seoul 130-701, Korea.

Neuroreport
|January 1, 2010
PubMed
Summary
This summary is machine-generated.

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Photochemically induced olfactory bulbectomy (P-bulbectomy) offers a new way to create animal models of depression. This method successfully ablates the olfactory bulb, leading to depression-like behaviors and neurohistological changes.

Area of Science:

  • Neuroscience
  • Animal Models
  • Depression Research

Background:

  • Depression is a prevalent mood disorder with complex pathophysiology.
  • Existing animal models for depression have limitations in reproducibility and relevance.
  • Targeting the olfactory bulb is a potential strategy for modeling depression.

Purpose of the Study:

  • To introduce photochemically induced olfactory bulbectomy (P-bulbectomy) as a novel method for creating an animal model of depression.
  • To evaluate the efficacy of P-bulbectomy in ablating the olfactory bulb.
  • To assess depression-related behaviors and neurohistological changes induced by P-bulbectomy.

Main Methods:

  • Rose Bengal photosensitizer was administered intravenously.
  • A cool halogen light was applied to the skull overlying the olfactory bulb for 10 minutes.

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  • Behavioral tests (open field, forced swimming) and neurohistological analyses were performed two weeks post-surgery.

    • Main Results:

    • P-bulbectomy resulted in complete and uniform olfactory bulb ablation in all subjects.
    • Induced depression-related behaviors included hyperactivity and increased immobility.
    • Neurohistological findings showed reduced choline-acetyltransferase-positive cells and decreased hippocampal cell proliferation.

    Conclusions:

    • P-bulbectomy is a convenient and reproducible method for generating an animal model of depression.
    • The model mimics key behavioral and neurobiological aspects of depression.
    • This technique provides a valuable tool for depression research.