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The relapse of hairy cell leukemia after a 32-year remission
J D Temple1, W J Harrington, C B McCoy
1Department of Medicine, University of Miami School of Medicine, Florida 33136.
Cancer
|April 1, 1991
Abstract:
The optimum therapy for hairy cell leukemia (HCL) is controversial. Dramatic responses to interferon-alpha and 2'-deoxycoformycin overshadow the established role of splenectomy in HCL, and patients currently can avoid surgery altogether. A case is presented of clinical remission lasting 32 years after splenectomy--a prolonged normal life, without medication or medical intervention. When relapse occurred, the patient's response to interferon-alpha was prompt and predictable. Prognostic variables are an important consideration at the time of diagnosis in predicting the response to splenectomy.