Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Management of Insomnia01:19

Management of Insomnia

The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
Insomnia01:27

Insomnia

Insomnia is a prevalent sleep disorder characterized by difficulty falling asleep, frequent awakenings during the night, and waking up too early without being able to return to sleep. People with insomnia often experience these disruptions at least three nights a week for at least one month. Chronic insomnia, which lasts for at least three months, can lead to increased anxiety, which in turn can worsen sleep difficulties, creating a cycle of sleeplessness and stress.
Multiple factors contribute...
REM Sleep Behavior Disorder01:15

REM Sleep Behavior Disorder

REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
Sedatives and Hypnotics Drugs: Miscellaneous Agents01:17

Sedatives and Hypnotics Drugs: Miscellaneous Agents

Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
CNS Depressants: Barbiturates and Benzodiazepines01:14

CNS Depressants: Barbiturates and Benzodiazepines

CNS depressants include drugs from the category of barbiturates and benzodiazepines. They are valuable medications for managing anxiety disorders and insomnia. Barbiturates, once used to induce and maintain sleep, have been replaced mainly by benzodiazepines due to barbiturate's toxicity, tolerance, and overdose risks. They interact with GABAA receptors, leading to sedation at low doses and potentially coma and death at higher doses. Phenobarbital, a long-acting barbiturate, possesses...
Operant Conditioning Intervention01:24

Operant Conditioning Intervention

Operant conditioning serves as a foundational principle in therapeutic interventions aimed at modifying maladaptive behaviors. Central to this approach is the notion that behaviors, both adaptive and maladaptive, are learned through reinforcement. By analyzing the environmental factors that reinforce problematic behaviors, clinicians can design interventions to weaken these reinforcements and replace maladaptive behaviors with healthier alternatives.
In operant conditioning, behaviors that are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of Prodromal Parkinson's Disease-Like Features in Long COVID With Dream-Enactment Behaviours.

Journal of sleep research·2026
Same author

Insomnia disorder.

Nature reviews. Disease primers·2026
Same author

Investigation of the "Not Better Explained" Diagnosis Criteria in Sleep Disorder Classifications: A Systematic Content Analysis and Critical Review.

Journal of sleep research·2026
Same author

The effectiveness of Cognitive behavioral therapy for insomnia on sleep EEG hyperarousal: a multicentric polysomnographic study.

Translational psychiatry·2026
Same author

Pharmacologic treatment data from chronic insomnia studies and the application to individuals with acute insomnia, a narrative review.

Sleep medicine reviews·2026
Same author

Corrigendum to "Long COVID as a risk factor for hypersomnolence and fatigue: insights from the 2nd International Covid Sleep Study Collaboration (ICOSS-2)" [Sleep Med. 136 (2025) 106764].

Sleep medicine·2026
Same journal

Sleep Mediates the Relationship Between Stress and Blood Pressure in Older African American Women: A Cross-Sectional RiSE Study.

Behavioral sleep medicine·2026
Same journal

Culturally Adapted Cognitive-Behavioral Therapy for Insomnia in Adults From the Arab World: A Three-Arm Randomized Pilot Study.

Behavioral sleep medicine·2026
Same journal

Addressing Daytime Symptoms of Insomnia with CBT-I: An Overview and Practical Applications.

Behavioral sleep medicine·2026
Same journal

Insomnia disorder and occupational demand in commercial freight driving: A qualitative analysis of symptoms and attributions.

Behavioral sleep medicine·2026
Same journal

Measuring What Matters in Sleep: Development and Validation of the Sleep Health Dimensions Questionnaire.

Behavioral sleep medicine·2026
Same journal

Considering Substance Use in Dysfunctional Beliefs About Sleep: Validation of the DBAS-S.

Behavioral sleep medicine·2026
See all related articles

Related Experiment Video

Updated: Jun 17, 2026

IntelliSleepScorer, a Software Package with a Graphic User Interface for Mice Automated Sleep Stage Scoring
04:54

IntelliSleepScorer, a Software Package with a Graphic User Interface for Mice Automated Sleep Stage Scoring

Published on: November 8, 2024

A computer device to deliver behavioral interventions for insomnia.

William T Riley1, Patricia Mihm, Albert Behar

  • 1National Heart, Lung, and Blood Institute, 6701 Rockledge Dr., MSC 7936, Bethesda, MD 20892, USA. wiriley@mail.nih.gov

Behavioral Sleep Medicine
|January 1, 2010
PubMed
Summary
This summary is machine-generated.

A computerized program for insomnia showed promise, with more users achieving remission from symptoms compared to a self-help manual. This automated approach to stimulus control and sleep restriction is feasible and warrants further investigation.

More Related Videos

Establishing a Device for Sleep Deprivation in Mice
05:05

Establishing a Device for Sleep Deprivation in Mice

Published on: September 22, 2023

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
04:33

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Published on: April 26, 2024

Related Experiment Videos

Last Updated: Jun 17, 2026

IntelliSleepScorer, a Software Package with a Graphic User Interface for Mice Automated Sleep Stage Scoring
04:54

IntelliSleepScorer, a Software Package with a Graphic User Interface for Mice Automated Sleep Stage Scoring

Published on: November 8, 2024

Establishing a Device for Sleep Deprivation in Mice
05:05

Establishing a Device for Sleep Deprivation in Mice

Published on: September 22, 2023

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
04:33

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Published on: April 26, 2024

Area of Science:

  • Behavioral sleep medicine
  • Digital health interventions
  • Psychology

Background:

  • Chronic primary insomnia affects a significant portion of the population.
  • Cognitive behavioral therapy for insomnia (CBT-I) is effective but access can be limited.
  • Automated delivery of CBT-I components may improve accessibility.

Purpose of the Study:

  • To compare a computerized stimulus control and sleep restriction program with a self-help manual for chronic primary insomnia.
  • To assess the feasibility and acceptance of a handheld computer-based intervention.
  • To evaluate treatment outcomes at 6 and 12 weeks.

Main Methods:

  • 90 participants with chronic primary insomnia were randomized to a computerized program or a self-help manual.
  • Interventions included stimulus control and sleep restriction strategies.
  • Outcomes were assessed using questionnaires and sleep diaries at 6 and 12 weeks.

Main Results:

  • The computerized program was well-accepted and utilized by participants.
  • No significant differences were found on primary questionnaire and sleep diary measures between groups.
  • Exploratory analyses showed a greater percentage of participants in the computerized group achieved remission from clinically significant insomnia at 6 weeks (based on PSQI and ISI).

Conclusions:

  • Computerized delivery of stimulus control and sleep restriction is a feasible and promising approach for insomnia treatment.
  • Further research is needed to confirm the efficacy of digital CBT-I interventions.
  • Automated behavioral interventions may offer a scalable solution for managing insomnia.