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Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

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Related Experiment Videos

Decoding the evolution of a breast cancer genome.

Philippe L Bedard1, Christos Sotiriou

  • 1Department of Medical Oncology, Jules Bordet Institute, Brussels, Belgium.

EMBO Molecular Medicine
|January 1, 2010
PubMed
Summary

Researchers sequenced the entire genome of a solid tumor for the first time. This advancement opens new avenues for understanding cancer genomes and improving clinical cancer care.

Area of Science:

  • Genomics
  • Oncology
  • Translational Medicine

Background:

  • The complete genome sequencing of solid tumors represents a significant milestone in cancer research.
  • Understanding the genomic landscape of cancer is crucial for developing targeted therapies and personalized medicine approaches.

Purpose of the Study:

  • To analyze the findings from the first successful whole-genome sequencing of a solid tumor.
  • To discuss the challenges and implications of translating cancer genome studies into clinical practice.

Main Methods:

  • Whole-genome sequencing of a solid tumor.
  • Bioinformatic analysis of genomic data.
  • Clinical application assessment.

Main Results:

Related Experiment Videos

  • Successful sequencing of the entire genome of a solid tumor reported by Shah et al.
  • Identification of key genomic alterations driving tumor development and progression.

Conclusions:

  • The ability to sequence solid tumor genomes offers unprecedented insights into cancer biology.
  • Significant challenges remain in integrating these findings into routine clinical cancer care and treatment strategies.