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Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Imbalances in Cardiac Output01:26

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CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
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Related Experiment Video

Updated: Jun 17, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Multi-plane mechanical dyssynchrony in cardiac resynchronization therapy.

Christopher L Kaufman1, Daniel R Kaiser, Kevin V Burns

  • 1Department of Research, St. Paul Heart Clinic, St. Paul, Minnesota 55102, USA. kauf0127@umn.edu

Clinical Cardiology
|January 1, 2010
PubMed
Summary
This summary is machine-generated.

Cardiac resynchronization therapy (CRT) improves heart function by reducing mechanical dyssynchrony. Baseline dyssynchrony predicts a better echocardiographic response to CRT, especially in longitudinal and radial planes.

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Area of Science:

  • Cardiology
  • Medical Imaging
  • Heart Failure Management

Background:

  • Cardiac resynchronization therapy (CRT) is a treatment for heart failure.
  • Assessing CRT's impact on mechanical dyssynchrony is crucial for optimizing patient outcomes.
  • Echocardiography offers a non-invasive method to evaluate cardiac mechanics.

Purpose of the Study:

  • To evaluate echocardiographic measures of dyssynchrony for predicting CRT response.
  • To characterize the global impact of CRT on cardiac motion.
  • To test the hypothesis that baseline dyssynchrony predicts echocardiographic response.

Main Methods:

  • Echocardiograms were performed pre- and post-CRT in 70 heart failure patients.
  • Longitudinal, radial, and circumferential dyssynchrony were quantified using speckle-tracking.
  • CRT echo response was defined as a ≥15% decrease in left ventricular end-systolic volume.

Main Results:

  • CRT significantly improved systolic function across all three planes.
  • The overall CRT echo response rate was 57%.
  • Patients with higher baseline dyssynchrony showed better response; CRT reduced dyssynchrony in responders.

Conclusions:

  • CRT enhances left ventricular function in longitudinal, radial, and circumferential dimensions.
  • Baseline longitudinal, radial, and interventricular dyssynchrony are modest predictors of reverse remodeling post-CRT.