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Updated: Jun 17, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Obstructive sleep apnoea increases risk of CVD
David Meek1, Indranil Chakravorty
1Sleep Disorders Unit, East & North Herts NHS Trust and Postgraduate Medical School, University of Hertfordshire.
Obstructive Sleep Apnea (OSA) affects millions, causing daytime sleepiness and serious health risks. Early diagnosis through sleep studies is crucial for effective management and improved quality of life.
Area of Science:
- Sleep Medicine
- Respiratory Medicine
- Public Health
Background:
- Obstructive Sleep Apnea (OSA) involves repeated airway closure during sleep, leading to apnea or hypopnea.
- Prevalence is estimated at 2-4% in middle-aged adults, comparable to diabetes and asthma.
- A significant majority (85-90%) of OSA sufferers remain undiagnosed.
Purpose of the Study:
- To highlight the prevalence and underdiagnosis of OSA.
- To emphasize the severe health consequences of untreated OSA.
- To guide clinicians in identifying potential OSA patients.
Main Methods:
- Review of population-based surveys on OSA prevalence.
- Discussion of clinical indicators for OSA suspicion.
- Overview of diagnostic methods, including polysomnography and portable sleep studies.
Main Results:
- OSA impacts daily functioning, increasing risks of accidents and poor performance.
- Untreated OSA is linked to hypertension, cardiovascular disease, cerebrovascular disease, depression, and mortality.
- Limited sleep studies can diagnose nearly 90% of OSA cases.
Conclusions:
- OSA is a common, underdiagnosed condition with significant health implications.
- Prompt identification and diagnosis are essential for mitigating risks.
- Accessible diagnostic tools facilitate widespread OSA detection.
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