Related Experiment Video
Updated: Jun 17, 2026
Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5
Published on: April 26, 2019
Renal histological findings in adults in Jamaica
A K Soyibo1, D Shah, E N Barton
1Caribbean Institute of Nephrology, Department of Medicine, The University of the West Indies, Kingston 7, Jamaica, West Indies. adedemo@hotmail.com
Insights
Focal and Segmental Glomerulosclerosis (FSGS), Minimal Change Disease (MCD), and Membranous Glomerulonephritis (MGN) are common primary glomerular diseases in Jamaica. Membranous Lupus Nephritis (MLN) is the most frequent type of lupus nephritis.
Area of Science:
- Nephrology
- Pathology
- Immunology
Background:
- A 2006 report identified FSGS, MCD, and MGN as common primary glomerular diseases in Jamaican kidney biopsies.
- Concerns over a small sample size in the 2006 study prompted a larger, three-year review.
Purpose of the Study:
- To determine the prevalence and patterns of glomerular diseases in Jamaica through a comprehensive review of kidney biopsies.
- To update the understanding of common primary and secondary glomerular diseases, including lupus nephritis.
Main Methods:
- A retrospective review of 224 native kidney biopsies performed between January 2005 and December 2007.
- Collection and analysis of demographic, clinical, and histological data from biopsy requisition forms.
Main Results:
- Primary glomerular diseases accounted for 39.2% of biopsies, with FSGS (34 cases), MGN (15 cases), and MCD (12 cases) being most common.
- Secondary glomerular diseases comprised 55.3% of biopsies, with lupus nephritis being the most frequent diagnosis (63.3% of secondary cases).
- Among lupus nephritis cases, Membranous Lupus Nephritis (MLN) was the predominant histological type (40.20%).
Conclusions:
- FSGS, MCD, and MGN remain the most common primary glomerular diseases identified via kidney biopsy in Jamaica.
- Membranous Lupus Nephritis (MLN) is the most prevalent histological subtype of lupus nephritis in this Jamaican cohort.
Background:
In 2006, it was reported that Focal and Segmental Glomerulosclerosis (FSGS), Minimal Change Disease (MCD) and Membranous Glomerulonephritis (MGN) were the commonest primary glomerular diseases identified from percutaneous kidney biopsies done in Jamaica for that year (n = 76). The sample size was thought to be small and might have affected the reported findings. So a three-year review of percutaneous kidney biopsies in Jamaica was carried out.
Methods:
Histology reports and clinical data were reviewed for percutaneous kidney biopsies performed from January 2005 to December 2007. Demographic data (age, gender), laboratory investigations such as serum urea, serum creatinine, proteinuria, haematuria, 24-hour urinary protein, and creatinine clearance, and clinical diagnosis were collected from the histology requisition form.
Results:
There was a total of 224 native kidney biopsies performed. There were 91 males (40.6%) and 133females (59.4%). Age distribution showed a total number of 25 paediatric cases (11.2%) and 199 adult cases (88.8%). Proteinuria was present in 171 cases (76.3%) and haematuria in 86 cases (38.4%). Of the total biopsies done, 78 cases (39.2%) had primary glomerular diseases, 110 cases (55.3%) had secondary glomerular diseases and 11 (5.5%) biopsies were reported as either normal or inadequate for histological diagnosis. The most common reasons indicated for percutaneous kidney biopsy were proteinuria, haematuria and staging of lupus nephritis. Most common histological findings for primary glomerular disease after percutaneous kidney biopsy were FSGS (n = 34), MGN (n = 15) and MCD (n = 12). In secondary glomerular diseases (n = 110), there were more females (70.8%) than males. Systemic lupus erythematosus was present in 63.3%. Histology of lupus nephritis according to the International Society of Nephrologists classification shows Membranous Lupus Nephritis [MLN] (40.20%), Diffuse Lupus Nephritis [DLN] (19.5%) and Minimal Mesangial Lupus Nephritis [MMLN] (14.3%) as the common histological types.
Conclusions:
The most common histological finding for primary glomerular disease following percutaneous kidney biopsy was FSGS, MCD and MGN. Membranous Lupus Nephritis was the commonest histological type for lupus nephritis in this series.
Related Concept Videos
01:27Liver Histology
Hepatocytes perform a variety of essential functions. They secrete...
01:26Stomach Histology
01:26Histology of the Large Intestine
The innermost mucosa layer comprises simple columnar epithelium, lamina propria, and muscularis mucosae. This layer is primarily populated with absorptive cells, tasked with water absorption, and goblet cells, responsible for secreting mucus to...
01:25Jaundice
01:27Histology of the Small Intestine
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
01:20Histology of the Gastrointestinal (GI) Tract
The mucosa is sometimes called a mucous membrane due to its mucus-secreting features. This membrane is composed of epithelium, which directly interacts with ingested substances, and the lamina propria, a layer...