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Related Concept Videos

Production of Formed Elements01:34

Production of Formed Elements

Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...

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Related Experiment Video

Updated: Jun 17, 2026

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood
07:26

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood

Published on: September 14, 2017

Endothelial progenitor cells--an evolving story.

Jeremy D Pearson1

  • 1King's College London, Cardiovascular Division, London SE1 9NH, UK. jeremy.pearson@kcl.ac.uk

Microvascular Research
|January 2, 2010
PubMed
Summary
This summary is machine-generated.

Most endothelial progenitor cells (EPCs) are actually angiogenic monocytes, not true endothelial progenitors. This finding impacts the future therapeutic applications of EPCs in regenerative medicine.

More Related Videos

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery
08:43

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Published on: February 14, 2017

Phenotypic and Functional Characterization of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood
13:46

Phenotypic and Functional Characterization of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood

Published on: April 13, 2012

Related Experiment Videos

Last Updated: Jun 17, 2026

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood
07:26

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood

Published on: September 14, 2017

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery
08:43

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Published on: February 14, 2017

Phenotypic and Functional Characterization of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood
13:46

Phenotypic and Functional Characterization of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood

Published on: April 13, 2012

Area of Science:

  • Cardiovascular Biology
  • Regenerative Medicine
  • Cell Biology

Background:

  • Endothelial progenitor cells (EPCs) were first described in 1997, revolutionizing the understanding of angiogenesis.
  • Clinical studies using bone marrow-derived EPCs to treat myocardial ischemia emerged within five years.
  • Improved therapeutic success necessitates a deeper understanding of EPC biology.

Purpose of the Study:

  • To summarize recent data on the cellular identity of EPCs.
  • To re-evaluate the classification of EPCs based on current evidence.
  • To explore the implications of this re-classification for cell-based therapies.

Main Methods:

  • Review of recent scientific literature and data.
  • Analysis of cellular markers and functional characteristics of EPCs.
  • Comparative assessment of EPCs against known endothelial and monocytic cell populations.

Main Results:

  • Most cells previously identified as EPCs do not exhibit true endothelial progenitor characteristics.
  • These cells are more accurately characterized as angiogenic monocytes.
  • This re-classification challenges the established understanding of EPC function.

Conclusions:

  • The majority of cells used in current EPC-based therapies may not be endothelial progenitors.
  • Re-classifying EPCs as angiogenic monocytes has significant implications for therapeutic strategies.
  • Future research and therapeutic development should consider this revised cellular identity for enhanced efficacy.