Related Experiment Video
Updated: Jun 17, 2026
Establishment of an Embryo Implantation Model In Vitro
Published on: June 21, 2024
Impact of embryo replacement depth on in vitro fertilization and embryo transfer outcomes
Bulent Tiras1, Mehtap Polat2, Umit Korucuoglu3
1Anatolia IVF Center, Ankara, Turkey; Gazi University Faculty of Medicine, Department of Obstetrics and Gynecology, Ankara, Turkey.
Objective:
To investigate the impact of embryo replacement depth on IVF and embryo transfer outcomes.
Design:
Retrospective analysis (May 2005 to November 2008) of 5,055 ultrasound-guided embryo transfers belonging to 3,930 infertile couples. The distance between the fundal endometrial surface and the catheter tip was measured and accordingly, patients were divided into five groups.
Setting:
Anatolia IVF Center, Ankara, Turkey.
Patient(S):
All patients enrolled in the IVF program undergoing embryo transfer.
Intervention(S):
No patient received any additional procedure or intervention.
Main Outcome Measure(S):
Clinical pregnancy rate (PR) and ongoing PR.
Result(S):
Mean total number of embryos transferred in groups 4 and 5 were significantly higher than in groups 2 and 3. Analysis of PRs and outcome of gestations in the five groups studied yielded similar PRs in all groups except for group 1.
Conclusion(S):
Pregnancy rates and ongoing PRs are higher if the embryos are replaced at a distance >10 mm from the fundal endometrial surface. In addition because significantly more embryos were replaced in cycles where the transfers occurred at a distance of >20 mm, a distance>10 mm to <20 mm seems to be the best site for embryo transfer to achieve higher PRs.
