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Updated: Jun 17, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
Published on: February 9, 2011
[Staphylococcus aureus infection in an acute geriatric unit]
Javier Gómez-Pavón1, Jaime Rodríguez Salazar, Eva Fernández de la Puente
1Servicio de Geriatría, Hospital Central de la Cruz Roja de Madrid, Madrid, España.
Objective:
The aim of this study was to determine the risk of mortality, functional decline and institutionalization, as well as the hospital cost associated with patients with methicillin-resistant Staphylococcus aureus (MRSA) infection in an Acute Geriatric Unit (AGU).
Material And Methods:
We retrospectively gathered data on patients admitted to the AGU over a 5-year period (from 1/1/2001 to 1/1/06). Mortality, institutionalization, functional impairment at discharge, length of hospital stay, and hospital costs were compared between patients with and without MRSA. MRSA infection was documented by the microbiology department using culture and antibiogram, as well as by clinical diagnosis of hospital infection registered in the medical record.
Results:
Data were obtained from 47 patients with MRSA (mean age 86.15+/-5.5 years) and from 4281 patients without MRSA (mean age 85.25+/-6 years). MRSA-infected patients had higher mortality (25.5% vs. 7.7%, p<0.001), worse functional status at discharge (Barthel index 39.43+/-33.05 vs. 55.24+/-34.99, p<0.01) and more frequent institutionalization (29% vs. 9%, p<0.001). Longer length of hospital stay (22.15+/-13.67 vs. 10.64+/-7.69 days, p<0.001) and higher hospital cost per patient (7517.71+/-4639.59 vs 3611.21+/-2609.98 euro, p<0.001) were also observed. In the multivariate analysis adjusted by age, sex, and baseline functional and cognitive status, MRSA infection was independently associated with higher mortality (OR=3.92; 95% CI=1.95-7.86), worse functional status at discharge (OR=2.48; 95% CI=1.22-5.01), institutionalization at discharge (OR=6.50; 95% CI=2.60-12.22), and substantial increase in length of hospital stay (Beta coefficient=11.55 days; 95% CI=9.32-13.75).
Conclusion:
MRSA infection in the AGU is associated with higher mortality, worse functional status at discharge and a higher incidence of institutionalization, as well as significantly longer length of stay and higher hospital costs.
Insights
Methicillin-resistant Staphylococcus aureus (MRSA) infection in acute geriatric units significantly increases mortality, functional decline, and institutionalization rates. This MRSA infection also leads to longer hospital stays and higher healthcare costs for elderly patients.
Area of Science:
- Geriatric Medicine
- Infectious Diseases
- Public Health
Context:
- Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant threat in healthcare settings, particularly for vulnerable elderly populations.
- Acute Geriatric Units (AGUs) manage complex health needs of older adults, making them susceptible to hospital-acquired infections like MRSA.
Purpose:
- To evaluate the impact of MRSA infection on mortality, functional status, and institutionalization among patients in an AGU.
- To determine the association between MRSA infection and hospital costs, including length of stay.
Summary:
- A retrospective study analyzed data from 47 MRSA-infected patients and 4281 non-infected patients in an AGU over five years.
- MRSA patients exhibited significantly higher mortality (25.5% vs. 7.7%), worse discharge functional status, and increased institutionalization (29% vs. 9%).
- MRSA infection was independently linked to a 3.92-fold increased mortality risk and a 2.48-fold increased risk of functional decline.
Impact:
- MRSA infection in AGUs is a critical factor contributing to adverse patient outcomes and increased healthcare expenditure.
- Findings highlight the need for enhanced infection control strategies and targeted interventions for MRSA prevention and management in geriatric care.
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