Related Experiment Video
Updated: Jun 17, 2026

Quantification of Hypopigmentation Activity In Vitro
Published on: March 6, 2019
Inhibitory effect of novel tetrahydropyrimidine-2(1H)-thiones on melanogenesis
P Thanigaimalai1, Ki-Cheul Lee, Seong-Cheol Bang
1College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon 305-764, Republic of Korea.
Abstract:
The series of imidazoldine-2-thiones 2 and tetrahydropyrimidine-2-thiones 3 were discovered as inhibitor of alpha-MSH-induced melanin production in melanoma B16 cells. The primary bioassay showed that 1-(4-ethylbenzyl)-tetrahydropyrimidine-2(1H)-thione 3e (>100% inhibition at 10 microM, IC(50)=1.2 microM) and 1-(4-tert-butylbenzyl)-tetrahydropyrimidine-2(1H)-thione 3f (>100% inhibition at 10 microM, IC(50)=0.76 microM) exhibited potent inhibitory effect against alpha-MSH-induced melanin production. Compounds 3 inhibit the biosynthesis of tyrosinase without affecting its catalytic activity in melanogenesis.
Related Concept Videos
Antiprotozoal Agents
Inhibition of Cdk Activity
Inhibition of CDK Activity