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Updated: Jun 17, 2026

DNAzyme 10-23 - Based Nanomachines for Nucleic Acid Recognition
Published on: February 9, 2024
Rapid sequencing of individual DNA molecules in graphene nanogaps
1Department of Physics, California State University Northridge, 18111 Nordhoff Street, Northridge, California 91330-8268, USA. postma@csun.edu
Abstract:
I propose a technique for reading the base sequence of a single DNA molecule using a graphene nanogap to read the DNA's transverse conductance. Because graphene is a single atom thick, single-base resolution of the conductance is readily obtained. The nonlinear current-voltage characteristic is used to determine the base type independent of nanogap-width variations that cause the current to change by 5 orders of magnitude. The expected sequencing error rate is 0% up to a nanogap width of 1.6 nm.
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