Related Experiment Video
Updated: Jun 17, 2026
09:34
Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
Published on: February 9, 2019
Development of repaglinide loaded solid lipid nanocarrier: selection of fabrication method
1Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi, India.
Current Drug Delivery
|January 5, 2010
Summary
The modified solvent injection method is superior for creating repaglinide solid lipid nanoparticles (RG-SLN) with better drug entrapment and slower release compared to ultrasonication. This method enhances repaglinide delivery.
Area of Science:
- Pharmaceutical Nanotechnology
- Drug Delivery Systems
- Materials Science
Background:
- Repaglinide (RG) is an antidiabetic drug requiring effective delivery systems.
- Solid lipid nanoparticles (SLNs) offer a promising platform for drug encapsulation and controlled release.
- Developing optimized methods for RG-SLN fabrication is crucial for improving therapeutic efficacy.
Purpose of the Study:
- To fabricate and characterize repaglinide-loaded solid lipid nanoparticles (RG-SLN) using stearic acid.
- To compare the efficacy of modified solvent injection and ultrasonication methods for RG-SLN preparation.
- To evaluate the impact of fabrication method on particle characteristics, entrapment efficiency, and in vitro drug release.
Main Methods:
- Formulation of RG-SLN using stearic acid, Pluronic F68, and soya lecithin.
- Preparation via modified solvent injection and ultrasonication techniques.
- Characterization included particle size, zeta potential, entrapment efficiency, total drug content, DSC, TEM, and in vitro release studies.
Main Results:
- Modified solvent injection yielded larger particle size (360nm) but higher entrapment efficiency (62.14%) compared to ultrasonication (281nm, lower entrapment).
- Zeta potential ranged from -23.10 to -26.01 mV, indicating good formulation stability.
- In vitro release showed slower drug release from modified solvent injection method (30% in 2 hrs) versus ultrasonication (50% in 2 hrs).
- Differential scanning calorimetry confirmed repaglinide's amorphous or molecular state within SLNs.
- Transmission electron microscopy revealed spherical morphology for all prepared RG-SLN.
Conclusions:
- The modified solvent injection method is more suitable for preparing repaglinide solid lipid nanoparticles using stearic acid due to superior drug entrapment and controlled release profiles.
- Optimized RG-SLN formulation holds potential for enhanced repaglinide therapy.
- Further studies are warranted to explore in vivo performance and therapeutic benefits.
