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Transfusion transmitted Chagas disease: is it really under control?
1Blood Bank, Hospital Sirio Libanês, Rua Adma Jafet 91, São Paulo, 01308-050, Brazil. snwendel@terra.com.br
Acta Tropica
|January 5, 2010
Summary
Transfusion-transmitted Chagas disease (American trypanosomiasis) is a growing concern due to migration. This review covers prevention strategies like screening and pathogen reduction to improve blood safety globally.
Area of Science:
- Transfusion Medicine
- Infectious Diseases
- Parasitology
Background:
- Chagas disease transmission via blood transfusion has been known for over 50 years.
- Historically overlooked, it is now a significant concern due to global migration.
- Its prevalence in non-endemic regions necessitates urgent attention in transfusion medicine.
Purpose of the Study:
- To review transfusion-related aspects of Chagas disease.
- To outline strategies for preventing transfusion-transmitted American trypanosomiasis.
- To enhance blood safety in both developing and developed countries.
Main Methods:
- Review of existing literature on Chagas disease and blood transfusion.
- Analysis of current and emerging prevention strategies.
- Discussion of serological testing, leukofiltration, and pathogen reduction.
Main Results:
- Donor screening and serological testing are primary prevention methods.
- Leukofiltration and pathogen reduction offer alternative or supplementary safety measures.
- Increased migration has made Chagas disease a global transfusion risk.
Conclusions:
- Effective strategies are crucial to mitigate transfusion-transmitted Chagas disease.
- A multi-pronged approach including screening and advanced technologies is needed.
- Global collaboration is essential to ensure blood safety and public health.
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