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Related Concept Videos

Tandem Mass Spectrometry01:21

Tandem Mass Spectrometry

Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and reduce chemical noise during analyte detection. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called...
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High-Resolution Mass Spectrometry (HRMS)01:15

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The resolution of a mass spectrometer depends on the efficiency of separating ions with different ion masses. The mass of an atom is approximated to the sum of the masses of protons and neutrons inside, considering the masses of protons and neutrons as equal. However, the masses of the proton (1.6726 × 10−24 g) and neutron (1.6749 × 10−24 g) are not truly equal. There is a minor error in the expression of atomic masses relative to the simplest atom of hydrogen. For example, the mass of helium...
MALDI-TOF Mass Spectrometry01:19

MALDI-TOF Mass Spectrometry

Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.Matrix-assisted laser desorption ionization (MALDI) is a commonly...
Mass Spectrometry: Complex Analysis01:21

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Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...
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Mass spectrometry is an analytical technique used to determine the molecular mass and molecular formula of a compound. The basic principle of mass spectrometry is to generate ions from the analyte molecule and measure these ion abundances against their molecular mass. One common type of ionization, known as electron ionization or EI, bombards the analyte molecules in the gas phase with high-energy electron beams. The electron beams displace an electron from the molecule and leave behind a...

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Real-time Breath Analysis by Using Secondary Nanoelectrospray Ionization Coupled to High Resolution Mass Spectrometry
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Real-time Breath Analysis by Using Secondary Nanoelectrospray Ionization Coupled to High Resolution Mass Spectrometry

Published on: March 9, 2018

Mass spectrometer for respiratory research.

R Arieli1

  • 1Israel Naval Medical Institute, IDF Medical Corps, P.O. Box 8040, 31080 Haifa, Israel. rarieli@netvision.net.il

Respiratory Physiology & Neurobiology
|January 5, 2010
PubMed
Summary
This summary is machine-generated.

Modified mass spectrometers offer a viable solution for respiratory research. These instruments provide fast gas analysis, crucial for studying respiratory physiology with improved response times.

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Area of Science:

  • Respiratory Physiology
  • Analytical Chemistry
  • Biomedical Engineering

Background:

  • Mass spectrometers are essential gas analyzers for respiratory research.
  • Many previously suitable mass spectrometers are no longer manufactured.
  • Existing models require modification to meet current research needs.

Purpose of the Study:

  • To adapt a commercially available mass spectrometer (MAX300-LG) for respiratory physiology studies.
  • To improve the response time of the mass spectrometer for physiological measurements.

Main Methods:

  • Bypassed the four-port valve of the MAX300-LG.
  • Connected the sampling capillary directly to the roughing pump.
  • Replaced the original capillary with a 2-m long, 0.15 mm internal diameter capillary.

Main Results:

  • The modifications successfully adapted the MAX300-LG for respiratory research.
  • The 90% response time was reduced to 85 ms.
  • This response time is suitable for dynamic respiratory physiology studies.

Conclusions:

  • The modified MAX300-LG mass spectrometer is a practical tool for respiratory research.
  • The modifications provide a cost-effective solution compared to specialized equipment.
  • This enhanced instrument facilitates advanced studies in respiratory physiology.