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Related Experiment Video

Updated: Jun 17, 2026

Du-Moxibustion in a Mouse Model of Ankylosing Spondylitis
04:47

Du-Moxibustion in a Mouse Model of Ankylosing Spondylitis

Published on: October 27, 2023

Decrease in antioxidant status of plasma and erythrocytes from patients with ankylosing spondylitis.

Agata Stanek1, Grzegorz Cieślar, Ewa Romuk

  • 1Department and Clinic of Internal Diseases, Angiology and Physical Medicine, Medical University of Silesia, 15 Batorego Street, 41-902 Bytom, Poland. astanek@tlen.pl

Clinical Biochemistry
|January 5, 2010
PubMed
Summary

Patients with ankylosing spondylitis (AS) show reduced antioxidant status, indicated by lower enzyme activities and increased oxidative stress markers. This suggests oxidative stress contributes to AS development.

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Last Updated: Jun 17, 2026

Du-Moxibustion in a Mouse Model of Ankylosing Spondylitis
04:47

Du-Moxibustion in a Mouse Model of Ankylosing Spondylitis

Published on: October 27, 2023

Area of Science:

  • Biochemistry
  • Immunology
  • Rheumatology

Background:

  • Ankylosing spondylitis (AS) is a chronic inflammatory disease.
  • Oxidative stress is implicated in the pathogenesis of various inflammatory conditions.

Purpose of the Study:

  • To evaluate the antioxidant status in plasma and erythrocytes of patients with ankylosing spondylitis (AS).
  • To assess the levels of key antioxidant enzymes and oxidative stress markers in AS patients.

Main Methods:

  • Compared 16 AS patients with 16 healthy volunteers.
  • Measured activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione transferase (GST).
  • Determined total antioxidant status (TAS) and malondialdehyde (MDA) concentration in plasma and erythrocytes.

Main Results:

  • AS patients exhibited significantly lower plasma activity of SOD, SOD-CuZn, and TAS compared to controls.
  • Erythrocyte activity of SOD, GPx, GST, and GR was significantly reduced in AS patients.
  • Malondialdehyde (MDA) concentration was significantly elevated in AS patients, indicating increased lipid peroxidation.

Conclusions:

  • A diminished antioxidant status, leading to oxidative stress, is observed in ankylosing spondylitis.
  • Oxidative stress may play a significant role in the pathogenesis of AS.
  • These findings highlight potential therapeutic targets for managing AS.