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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)

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Studies on glyphosate-induced carcinogenicity in mouse skin: a proteomic approach

Jasmine George1, Sahdeo Prasad, Zafar Mahmood

  • 1Proteomics Laboratory, Indian Institute of Toxicology Research (CSIR), Mahatma Gandhi Marg, Lucknow 226001 UP, India.

Journal of Proteomics
|January 5, 2010
PubMed

Insights

Glyphosate, a common herbicide, demonstrates tumor-promoting effects in mouse skin. Its mechanism involves altering protein expression similar to TPA, suggesting potential carcinogenic risks.

Area of Science:

  • Toxicology
  • Carcinogenesis
  • Proteomics

Background:

  • Glyphosate is a widely used herbicide with known toxic effects.
  • The carcinogenic potential of glyphosate in non-target species remains largely unknown.
  • Understanding glyphosate's impact on carcinogenesis is crucial for public health.

Purpose of the Study:

  • To investigate the carcinogenic effects of glyphosate using a mouse skin model.
  • To identify protein expression changes associated with glyphosate-induced skin carcinogenesis.
  • To explore the potential mechanism of glyphosate's action in skin cancer development.

Main Methods:

  • A two-stage mouse skin carcinogenesis model was employed.
  • Proteomic analysis, including 2D gel electrophoresis and mass spectrometry, was utilized.
  • Immunoblotting was used to validate differential protein expression.

Main Results:

  • Glyphosate exhibited tumor-promoting activity in the mouse skin model.
  • Proteomic analysis revealed differential expression of 22 protein spots.
  • Nine proteins, including translation elongation factor eEF-1 alpha and superoxide dismutase [Cu-Zn], showed similar expression patterns in glyphosate and TPA-treated groups.

Conclusions:

  • Glyphosate possesses tumor-promoting potential in skin carcinogenesis.
  • The mechanism of glyphosate-induced skin carcinogenesis may be similar to that of TPA.
  • Specific proteins like calcyclin and calgranulin-B could serve as biomarkers for glyphosate-induced skin cancer.

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