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Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

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Hydrocortisone induced hypertrophic cardiomyopathy.

J Vimala, Atul Prabhu, Sreeja Pavithran

International Journal of Cardiology

|January 5, 2010

Summary

Steroid administration in a preterm infant caused recurrent hypertrophic obstructive cardiomyopathy (HOCM). The condition resolved upon drug cessation, indicating a direct link between steroids and HOCM development in neonates.

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Area of Science:

Neonatal Medicine
Pediatric Cardiology
Pharmacology

Background:

Broncho-pulmonary dysplasia is a common complication in preterm infants.
Steroids are sometimes used to manage broncho-pulmonary dysplasia.
Hypertrophic obstructive cardiomyopathy (HOCM) is a cardiac condition characterized by thickening of the heart muscle.

Observation:

A preterm infant receiving hydrocortisone for broncho-pulmonary dysplasia developed HOCM.
Echocardiography revealed left ventricular hypertrophy and outflow tract obstruction.
The cardiac abnormalities resolved after discontinuing hydrocortisone.

Findings:

Recurrent HOCM developed in the infant following a second course of hydrocortisone.
This suggests a causal relationship between steroid administration and HOCM in this patient.
The findings highlight a potential adverse effect of steroids in preterm neonates.

Implications:

Steroid therapy in preterm infants may pose a risk for developing HOCM.
Careful cardiac monitoring is warranted in neonates treated with steroids.
Further research is needed to understand the mechanisms and prevalence of steroid-induced HOCM.