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Corticotropin and nonshivering thermogenesis.

M C Laury, R Portet

    Experientia
    |November 15, 1977
    PubMed
    Summary

    Chronic corticotropin treatment altered norepinephrine

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    Area of Science:

    • Physiology
    • Endocrinology
    • Thermogenesis

    Background:

    • Norepinephrine is a key mediator of nonshivering thermogenesis.
    • Cold acclimatization influences metabolic responses to catecholamines.

    Purpose of the Study:

    • To investigate the effect of chronic corticotropin administration on the calorigenic action of norepinephrine.
    • To explore the mechanisms underlying corticotropin's influence on thermogenesis.

    Main Methods:

    • Rats were subjected to chronic corticotropin treatment.
    • Calorigenic effects of norepinephrine were measured in control and cold-acclimatized rats.
    • Metopirone administration was used to assess the role of corticosterone.

    Main Results:

    • Chronic corticotropin reduced the calorigenic effect of norepinephrine in cold-acclimatized rats.
    • In control rats, corticotropin potentiated norepinephrine's calorigenic effect.
    • The observed effects were independent of changes in plasma corticosterone levels.

    Conclusions:

    • Corticotropin may competitively interact with norepinephrine receptor sites.
    • This interaction influences nonshivering thermogenesis, particularly in cold-acclimatized states.
    • The findings suggest a complex regulatory role of corticotropin in metabolic heat production.

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