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Related Concept Videos

Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
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Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
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Myasthenia Gravis ll: Pathophysiology

The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
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Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
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Acute Kidney Injury VI: Nursing Management

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Related Experiment Video

Updated: Jun 17, 2026

Manual Muscle Testing: A Method of Measuring Extremity Muscle Strength Applied to Critically Ill Patients
09:44

Manual Muscle Testing: A Method of Measuring Extremity Muscle Strength Applied to Critically Ill Patients

Published on: April 12, 2011

Intensive care unit-acquired weakness: framing the topic.

Jean-Louis Vincent1, Michelle Norrenberg

  • 1Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium. jlvincen@ulb.ac.be

Critical Care Medicine
|January 5, 2010
PubMed
Summary
This summary is machine-generated.

Intensive care can cause prolonged weakness, leading to disability. Reducing sedative use and promoting early exercise may help manage this common complication.

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Area of Science:

  • Critical Care Medicine
  • Neurology
  • Physical Therapy

Background:

  • Intensive care unit (ICU) stays can lead to prolonged weakness, a significant complication.
  • This ICU-acquired weakness increases patient morbidity during hospitalization and causes long-term functional disability.
  • Diagnosing and treating ICU-acquired weakness remains challenging, with no specific therapies currently available.

Purpose of the Study:

  • To review the management strategies for intensive care unit-acquired weakness.
  • To highlight the importance of reducing sedative use and promoting early mobilization and exercise.

Main Methods:

  • Literature review on the sequelae of intensive care.
  • Analysis of current management approaches for ICU-acquired weakness.
  • Discussion of early mobilization and exercise as therapeutic interventions.

Main Results:

  • Prolonged weakness is a common and difficult-to-diagnose complication of intensive care.
  • Current management focuses on mitigating effects rather than specific treatment.
  • Reducing sedative exposure and encouraging early physical activity are key strategies.

Conclusions:

  • Intensive care unit-acquired weakness significantly impacts patient recovery and long-term function.
  • Early mobilization and exercise, alongside reduced sedation, are crucial for managing this condition.
  • Further research into specific therapies for ICU-acquired weakness is warranted.