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Related Experiment Video

Updated: Jun 17, 2026

A Rat Model of Pouchitis Following Proctocolectomy and Ileal Pouch-Anal Anastomosis Using Dextran Sulfate Sodium

A Rat Model of Pouchitis Following Proctocolectomy and Ileal Pouch-Anal Anastomosis Using Dextran Sulfate Sodium

Published on: May 31, 2024

Cutis laxa: a case report and an update.

L E Fatmi¹, M S Haque, A H Mollah

¹Department of Paediatrics, Dhaka Medical College, Dhaka, Bangladesh.

Mymensingh Medical Journal : MMJ

|January 5, 2010

Summary

This case report details a 10-year-old Bangladeshi girl with Cutis Laxa, a rare genetic skin disorder. The findings highlight severe skin laxity and associated cardiopulmonary complications, emphasizing the need for early diagnosis of this condition.

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Last Updated: Jun 17, 2026

A Rat Model of Pouchitis Following Proctocolectomy and Ileal Pouch-Anal Anastomosis Using Dextran Sulfate Sodium

A Rat Model of Pouchitis Following Proctocolectomy and Ileal Pouch-Anal Anastomosis Using Dextran Sulfate Sodium

Published on: May 31, 2024

Area of Science:

Dermatology
Genetics
Pediatrics

Background:

Cutis Laxa (CL) is a rare genetic connective tissue disorder characterized by generalized, progressive, and premature aging of the skin.
Few cases are reported globally, making each new report valuable for understanding its prevalence and presentation.

Observation:

A 10-year-old girl presented with striking facial features including loose, inelastic, and hyper-extensible skin, downward slanting palpebral fissures, periorbital edema, a broad flat nose, sagging cheeks, and large ears.
Skin biopsy revealed fragmentation of elastic tissue and dermal collagen, indicative of Cutis Laxa.
Radiological findings included hypertranslucent lung fields, cardiomegaly, and signs suggestive of corpulmonale with bronchiectasis.

Findings:

The patient exhibited classic signs of Cutis Laxa, including significant skin laxity and characteristic facial dysmorphia.
Cardiopulmonary involvement was evident, with echocardiography confirming dilated cardiac chambers and pulmonary artery, consistent with corpulmonale.
Histopathological examination of the skin biopsy confirmed the diagnosis by showing elastolysis.

Implications:

This report represents the first documented case of Cutis Laxa in Bangladesh, expanding the known geographical distribution of the disorder.
The case underscores the importance of recognizing the diverse clinical manifestations of Cutis Laxa, particularly in pediatric populations.
Comprehensive evaluation including skin biopsy and cardiopulmonary assessments is crucial for accurate diagnosis and management of Cutis Laxa and its associated complications.