[Antidiuretic activity of dithiocarbamic acid derivatives]

Chemically pure dithiocarbamates, thiuramsulphides and ethylene-bis-dithiocarbamates display a well-marked antidiuretic action. They materially reduce diuresis, natri- and kaliuresis in rats (1/5 LD(50) per 1 kg into the stomach) and in dogs (sodium N, N-diethyl-dithiocarbamate-into renal artery). Without changing the tubular reabsorption DEDTC inhibits the glomerular filtration of the dogs' kidneys. Furosemide (lasix) prevents the development of the an antidiuletic anidiuretic effect and reduction of the sodium and potassium excretion provoked in rats with DEDTC, zinc N, N', N"-tetraethylthiuram-disulphide and ethylene-bis-dithiocarbamate. Furosemide is recommended for the treatment of acute poisonings with dithiocarbaminic acid derivatives.