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Updated: Jun 17, 2026

Solid Lipid Nanoparticles (SLNs) for Intracellular Targeting Applications

Solid Lipid Nanoparticles (SLNs) for Intracellular Targeting Applications

Published on: November 17, 2015

Formulation and targeting efficiency of Cisplatin engineered solid lipid nanoparticles.

R C Doijad¹, F V Manvi, D M Godhwani

¹Department of Pharmaceutics, K. L. E. S's College of Pharmacy, JNMC Campus, Nehru Nagar, Belguam-590 010, India.

Indian Journal of Pharmaceutical Sciences

|January 5, 2010

Summary

This summary is machine-generated.

This study developed a novel solid lipid nanoparticulate delivery system for cisplatin, enhancing its therapeutic efficacy and reducing toxicity. The nanoparticles showed promising preferential targeting to the liver in vivo.

Keywords:

Cisplatin in vivo tissue distribution solid lipid nanoparticles

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Published on: December 13, 2015

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Solid Lipid Nanoparticles (SLNs) for Intracellular Targeting Applications

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Published on: November 17, 2015

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance

Published on: December 13, 2015

Area of Science:

Nanotechnology
Drug Delivery Systems
Pharmacology

Background:

Cisplatin is a widely used chemotherapy drug but suffers from significant toxicity and a narrow therapeutic index.
Improving cisplatin's efficacy and reducing its side effects are critical challenges in cancer treatment.

Purpose of the Study:

To develop and characterize a solid lipid nanoparticulate (SLN) delivery system for cisplatin.
To evaluate the enhanced efficacy, reduced toxicity, and improved therapeutic index of cisplatin-loaded SLNs.

Main Methods:

Cisplatin-loaded SLNs were prepared using the microemulsification method with stearic acid, soy lecithin, and sodium glycolate.
Formulations were characterized for size, surface morphology, zeta potential, entrapment efficiency, and in vitro drug release.
In vivo drug targeting studies and stability assessments were conducted.

Main Results:

Oval-shaped SLNs with diameters ranging from 250-500 nm were obtained.
Entrapment efficiency varied from 47.59% to 74.53%, with zeta potential between -9.8 to -11.2 mv.
In vitro release studies showed cumulative drug release up to 97.22% in 16 hours, and in vivo studies indicated preferential targeting to the liver, brain, and lungs.

Conclusions:

The developed solid lipid nanoparticulate system offers a promising approach for improving cisplatin's therapeutic index.
SLN formulation enhances cisplatin delivery and exhibits preferential accumulation in target organs, potentially leading to improved cancer therapy outcomes.