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Evaluation of antispasmodic activity of different Shodhit guggul using different shodhan process
Rachana Kamble1, Sadhana Sathaye, D P Shah
1University Institute of Chemical Technology, N. Parekh Marg, Matunga, Mumbai-400 019, India.
Indian Journal of Pharmaceutical Sciences
|January 5, 2010
Summary
Ayurvedic processing, known as shodhan vidhi, enhances guggul
Area of Science:
- Ayurvedic medicine
- Pharmacology
Background:
- Shodhan vidhi is an Ayurvedic process to enhance compound efficacy and reduce toxicity.
- Guggul is often processed using shodhan vidhi with various substances before formulation.
Purpose of the Study:
- To evaluate the antispasmodic activity of processed guggul (shodhit guggul) compared to unprocessed guggul (ashudha guggul).
Main Methods:
- Isolated ileum tissues from guinea pigs and Wistar rats were used.
- Antispasmodic activity was tested against spasmogens like acetylcholine, histamine, and barium chloride.
Main Results:
- Processed guggul (shodhit guggul) demonstrated superior antispasmodic activity compared to unprocessed guggul (ashudha guggul).
- Guggul processed with gulvel and triphala showed significant antispasmodic effects when acetylcholine was the spasmogen.
Conclusions:
- Shodhan vidhi significantly enhances the therapeutic properties, specifically the antispasmodic activity, of guggul.
- Specific processing agents like gulvel and triphala yield notable improvements in guggul's efficacy.
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