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Formulation development and release studies of indomethacin suppositories
1Department of Pharmacy, Shri Govindram Seksaria Institute of Technology and Science, 23, Park Road, Indore-452 003, India.
Indian Journal of Pharmaceutical Sciences
|January 5, 2010
Summary
Water-soluble bases offer superior indomethacin suppository release compared to oil-soluble bases. Lower concentrations of Tween 80 enhanced drug release, with water-soluble bases showing better stability.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Formulation Development
Background:
- Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) commonly used for pain and inflammation management.
- Suppositories offer an alternative route for drug administration, bypassing first-pass metabolism.
- Formulation excipients significantly influence drug release profiles and stability.
Purpose of the Study:
- To evaluate the in vitro release of indomethacin from suppositories formulated with different bases.
- To investigate the impact of Tween 80 concentration on indomethacin release kinetics.
- To assess the physical stability of indomethacin suppositories.
Main Methods:
- Preparation of indomethacin suppositories using water-soluble and oil-soluble bases.
- In vitro drug release studies conducted using USP I and modified continuous flow apparatus.
- Stability testing of prepared suppositories under specified conditions.
Main Results:
- Water-soluble bases demonstrated significantly higher indomethacin release rates compared to oil-soluble bases.
- The modified continuous flow apparatus showed greater drug release than the USP I apparatus.
- Lower concentrations (1%) of Tween 80 resulted in enhanced drug release compared to higher concentrations (5%).
- Suppositories formulated with water-soluble bases exhibited better stability than those with oil-soluble bases.
Conclusions:
- Water-soluble bases are more suitable for developing indomethacin suppositories with improved drug release.
- Tween 80 concentration plays a critical role in modulating indomethacin release, with lower levels being more effective.
- Formulation choice impacts both drug release performance and suppository stability.
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