Related Experiment Video
Updated: Jun 17, 2026

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
Development of mouth dissolving tablets of clozapine using two different techniques
R S Masareddy1, R V Kadia, F V Manvi
1Department of Pharmaceutics, K. L. E. S's College of Pharmacy, Nehrunagar, Belgaum-590 010, India.
Abstract:
Mouth dissolving tablets constitute an innovative dosage form that overcomes the problems of swallowing and provides a quick onset of action. In view of enhancing bioavailability an attempt has been made to study two different methods direct compression and sublimation in formulation of mouth dissolving tablets of clozapine. Total four formulations using various superdisintegrants and subliming agents were prepared. All prepared formulations were evaluated for physico-chemical parameters. The formulations exhibited good disintegration properties with total disintegration time in the range of 25 to 35 s. Comparative evaluation of two methods showed direct compression method is a better alternative to sublimation method as its formulations rapidly disintegrate in oral cavity. In vitro cumulative percentage drug release for formulations prepared by direct compression with explotab superdisintegrants shows 99.79 while sublimation method using camphor 93.58 release in 12 min. Kinetic studies indicated that all the formulations followed first order release with diffusion mechanism.
Related Concept Videos
Factors Influencing Drug Absorption: Pharmaceutical Parameters
Oral Drug Delivery Systems: Introduction
Factors Affecting Dissolution: Particle Size and Effective Surface Area
Drug Delivery Systems: Different Types
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules
