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Related Concept Videos

Modified-Release Drug Delivery Systems: Influencing Factors01:20

Modified-Release Drug Delivery Systems: Influencing Factors

Modified-release drug delivery systems are designed to optimize the therapeutic effect of drugs by minimizing side effects, reducing the dosage required, and controlling drug release to align with pharmacokinetic and pharmacodynamic needs. The system depends on two key factors: the drug's release from the formulation and its movement through the body to the target site. Unlike conventional dosage forms, where absorption is the limiting step, the rate of drug release is the key determinant in...
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH01:21

Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH

Drug absorption within the gastrointestinal (GI) tract is a complex process influenced by several critical factors, including the site pH, the drug's dissociation constant (pKa), and the drug's lipophilicity. The GI tract exhibits a pH gradient, with an acidic environment in the stomach and a more alkaline environment in the small intestine. This pH variation directly affects the ionization state of drugs.
A drug's pKa and the pH of the gastrointestinal (GI) tract play crucial roles in drug...
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
Factors Influencing Drug Absorption: Drug Dissolution01:27

Factors Influencing Drug Absorption: Drug Dissolution

The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...
Factors Influencing Drug Absorption: Physicochemical Parameters01:22

Factors Influencing Drug Absorption: Physicochemical Parameters

The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...

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Related Experiment Video

Updated: Jun 17, 2026

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
11:30

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Published on: August 31, 2019

Factors affecting drug release from liposomes.

Lars H Lindner1, Martin Hossann

  • 1CCG-Hyperthermia, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany. Lars.Lindner@med.uni-muenchen.de

Current Opinion in Drug Discovery & Development
|January 5, 2010
PubMed
Summary

This review summarizes methods to control drug release from liposomes (lipid-based nanoparticles). Strategies focus on optimizing drug delivery for enhanced therapeutic efficacy in medicine.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Pharmaceutics

Background:

  • Liposomes are extensively utilized nanocarriers in medical applications.
  • Tumor-specific drug delivery often relies on passive accumulation or active targeting of liposomes.
  • Effective drug delivery necessitates controlled release of the encapsulated therapeutic agent at the target site.

Purpose of the Study:

  • To review and summarize diverse strategies for modulating drug release from liposomes.
  • To highlight the importance of controlled release for effective liposomal drug delivery.
  • To discuss various triggers and modifications influencing liposome drug release.

Main Methods:

  • Review of literature on liposome formulation and drug release mechanisms.

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Last Updated: Jun 17, 2026

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
11:30

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Published on: August 31, 2019

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes
09:51

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes

Published on: March 3, 2020

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
11:27

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

Published on: August 9, 2022

  • Analysis of passive and active targeting strategies for liposomes.
  • Examination of environmental and external stimuli-responsive drug release systems.
  • Discussion of factors influencing drug release, including liposome composition and drug properties.

    • Main Results:

    • Liposome drug release is influenced by membrane composition, drug properties, and release triggers.
    • Passive targeting relies on enhanced permeability and retention (EPR) effect in tumors.
    • Active targeting employs surface ligands for specific cell recognition.
    • Both internal (pH, enzymes) and external (heat, ultrasound) stimuli can trigger drug release.
    • Modifications to liposome design are crucial for controlled therapeutic agent release.

    Conclusions:

    • Controlled drug release is critical for the efficacy of liposomal drug delivery systems.
    • A variety of methods, including stimuli-responsive designs, can be employed to achieve targeted drug release.
    • Further research into optimizing liposome-based drug release holds significant therapeutic potential.