Related Experiment Video
Updated: Jan 8, 2026
Assessment of Chemical Toxicity in Adult Drosophila Melanogaster
Published on: March 24, 2023
[Study on reproductive and immune toxicity of male rats exposed to As2O3]
Yajuan Xia1, Guang Hao, Ying Yang
1Inner Mongolia Center for Endemic Disease Control and Research, Huhhot 010031, China. yajxia@126.com
Objective:
To study on reproductive and immune toxicity of male rats exposed to subacute As2O3.
Methods:
24 male rats of KM-strain were divided into four groups and were given by gavage deionized water, 2.0, 4.0 and 8.0 mg As/(kg x bw) for 7 days. After the exposure, the rats were killed and the testis, epididymis were collected and analysed.
Results:
(1) In comparison with control, testicular and epididymal weights were lower than those of high dose group (P < 0.05), but there were no difference of testicular indexes between exposed group and control. The stained sperm count were lower than those of arsenic exposure group (P > 0.05), and malformation rate of sperm were significant increase in middle- and high-dose group (P < 0.05); (2) Compared to control, the weight and index of immune organ was decrease in middle-and high-dose group, and the spleen weight and index was significantly lower in high-dose group (P < 0.05).
Conclusion:
As2O3 can induce reproductive and immunotoxicity in male mice.
Related Concept Videos
01:26Toxic Reactions: Overview
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
01:25Mutagenicity and Carcinogenicity