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Updated: Jun 17, 2026
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A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
Relationship between CX3CR1 genetic polymorphism and carotid atherosclerosis
Renliang Zhao1, Yongjun Wang, Ruowu Shen
1Department of Neurology, Affiliated Hospital, Medical College, Qingdao University, No. 38 Dengzhou Road, Qingdao, Shandong, China.
Summary
The CX3CR1 gene
Area of Science:
- Genetics and cardiovascular research
Background:
- Carotid atherosclerosis (CAS) is a significant risk factor for stroke.
- Genetic variations may influence CAS susceptibility.
- The CX3CR1 gene's role in CAS requires further investigation.
Purpose of the Study:
- To examine the association between CX3CR1 gene polymorphisms (V249I and T280M) and CAS.
- To determine if these polymorphisms are risk factors for CAS in a Han Chinese population.
Main Methods:
- Case-control study involving 328 CAS patients and 292 healthy controls.
- Genotyping of CX3CR1 V249I and T280M polymorphisms using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP).
Main Results:
- A significantly lower frequency of the M280 allele (from T280M polymorphism) was observed in the CAS group compared to controls.
- Logistic regression identified the decreased M280 allele frequency as an independent risk factor for CAS.
Conclusions:
- The M280 allele of the CX3CR1 T280M polymorphism may have a protective effect against carotid atherosclerosis.
- CX3CR1 gene variations could be a potential biomarker for CAS risk assessment.
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