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Mouse ferritin H sequences map to chromosomes 3, 6, and 19
A Yachou1, M G Mattei, N Roeckel
1Laboratoire de Genetique Moleculaire, Faculte X. Bichat, Marseille, France.
Genomics
|January 1, 1991
Summary
Mouse genome analysis reveals three to four ferritin H-related sequences. Chromosomal mapping indicates these sequences are located on chromosomes 3, 6, and 19, with chromosome 19 likely housing the structural H gene.
Area of Science:
- Genomics
- Molecular Biology
- Mammalian Genetics
Background:
- The human and rodent genomes possess multiple copies of ferritin H and L subunit sequences.
- The precise number of expressed genes for these subunits remains undetermined.
Purpose of the Study:
- To isolate a cDNA for the mouse ferritin H subunit.
- To determine the genomic location of mouse ferritin H subunit genes using chromosomal in situ hybridization.
Main Methods:
- Isolation of mouse ferritin H subunit cDNA.
- Chromosomal in situ hybridization using 3H-labeled cDNA on R-banded metaphase chromosomes from mouse lymphocytes.
- Identification of chromosome locations for ferritin H-related sequences.
Main Results:
- The mouse genome contains three to four ferritin H-related sequences.
- These sequences were mapped to mouse chromosomes 3, 6, and 19.
- Synteny homology suggests the mouse chromosome 19 sequence corresponds to the structural H gene.
Conclusions:
- Mouse chromosome 19 harbors the structural ferritin H gene.
- The study elucidates the genomic organization of ferritin H subunit genes in mice.
- Comparative genomics supports conserved gene locations between human and mouse for ferritin H.