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Cognitive functioning in chronic fatigue syndrome: a meta-analysis.

S J Cockshell¹, J L Mathias

¹School of Psychology, The University of Adelaide, Adelaide, South Australia, Australia.

Psychological Medicine

|January 6, 2010

Summary

People with chronic fatigue syndrome (CFS) experience significant cognitive impairments, particularly in attention, memory, and processing speed. This meta-analysis confirms these deficits, highlighting key areas affected by CFS.

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Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

Area of Science:

Neuroscience
Psychology
Medical Research

Background:

Cognitive problems are a major disabling symptom for individuals with chronic fatigue syndrome (CFS).
Previous research on cognitive deficits in CFS has yielded inconsistent findings due to methodological variations.
A meta-analysis was needed to clarify the pattern and extent of cognitive impairments in CFS.

Purpose of the Study:

To conduct a meta-analysis of studies on cognitive functioning in CFS.
To identify the specific pattern and magnitude of cognitive deficits associated with CFS.
To provide a clearer understanding of the cognitive impact of chronic fatigue syndrome.

Main Methods:

A systematic literature search was performed on PubMed and PsycINFO databases.
50 eligible studies examining cognitive functioning in CFS between 1988 and 2008 were included.
Weighted Cohen's d effect sizes, confidence intervals, and fail-safe Ns were calculated for cognitive scores.

Main Results:

Cognitive deficits were identified in attention, memory, and reaction time for individuals with CFS.
No significant deficits were observed in tests of fine motor speed, vocabulary, reasoning, or global functioning.
Information processing speed (both simple and complex) and sustained working memory were impaired.

Conclusions:

Individuals with CFS exhibit moderate to large impairments in information processing speed.
Sustained attention and working memory tasks are significantly affected in persons with CFS.
These findings underscore the substantial cognitive impact of chronic fatigue syndrome.