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Related Concept Videos

Pleural Disorders: Types and Brief Description01:30

Pleural Disorders: Types and Brief Description

The pleura is a vital part of the respiratory system. It's a double-layered membrane surrounding the lungs and lining the chest cavity. The two layers of the pleura are:
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: Jun 17, 2026

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
07:54

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

Malignant mesothelioma.

R M Rudd1

  • 1London Lung Cancer Group, 54 New Cavendish Street, London, UK. dr@robinrudd.com

British Medical Bulletin
|January 6, 2010
PubMed
Summary
This summary is machine-generated.

Mesothelioma, a cancer linked to asbestos exposure, is becoming more common. While amphibole fibers are more potent carcinogens than chrysotile, new treatments offer hope.

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Last Updated: Jun 17, 2026

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Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

Published on: October 2, 2015

Area of Science:

  • Oncology
  • Environmental Medicine
  • Pathology

Background:

  • Mesothelioma is a malignant tumor of the pleura or peritoneum.
  • It is primarily caused by asbestos exposure.
  • The incidence of mesothelioma is increasing, with a poor prognosis and short survival.

Purpose of the Study:

  • To review the current understanding of mesothelioma etiology and treatment.
  • To highlight areas of agreement and controversy in the field.
  • To discuss emerging research and future directions.

Main Methods:

  • Review of medical literature.
  • Incorporation of personal clinical experience.

Main Results:

  • Amphibole asbestos fibers are significantly more potent in causing mesothelioma than chrysotile.
  • A minority viewpoint suggests chrysotile-related mesotheliomas are due to tremolite contamination.
  • The hypothesis linking Simian virus 40 to mesothelioma is losing support.

Conclusions:

  • Genetic variations may influence susceptibility to asbestos-induced carcinogenesis.
  • Chemotherapy regimens, including pemetrexed and cisplatin, show promise in prolonging survival and managing symptoms.
  • Further research is needed on targeted therapies and the role of surgery.