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Mouse Models Of Helicobacter Infection And Gastric Pathologies
07:43

Mouse Models Of Helicobacter Infection And Gastric Pathologies

Published on: October 18, 2018

Matrix metalloproteinase-7 and premalignant host responses in Helicobacter pylori-infected mice

Seth R Ogden1, Jennifer M Noto, Shannon S Allen

  • 1Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232-2279, USA.

Cancer Research
|January 6, 2010
PubMed

Insights

Matrix metalloproteinase-7 (MMP-7) deficiency exacerbates Helicobacter pylori-induced gastritis in mice. MMP-7 appears to protect the gastric mucosa, potentially reducing cancer risk by mitigating inflammation and cellular turnover.

Area of Science:

  • Gastroenterology
  • Immunology
  • Oncology

Background:

  • Helicobacter pylori infection is a primary cause of gastric adenocarcinoma.
  • Matrix metalloproteinase-7 (MMP-7) is implicated in tumorigenesis and modulated by H. pylori.
  • MMP-7 influences the gastric microbial environment and epithelial cell behavior.

Purpose of the Study:

  • To investigate the role of MMP-7 in H. pylori-induced gastritis using a murine model.
  • To determine if MMP-7 deficiency impacts gastric inflammation, cellular turnover, and bacterial eradication.

Main Methods:

  • Utilized a transgenic murine model deficient in MMP-7 (mmp-7-/-).
  • Infected mice with H. pylori to induce gastritis.
  • Assessed gastric inflammation, Th1/Th17 pathways, epithelial cell turnover, proliferation, and apoptosis.

Main Results:

  • MMP-7 deficient mice exhibited increased gastric inflammation upon H. pylori infection.
  • Enhanced gastritis was associated with Th1 and Th17 immune responses.
  • Accelerated epithelial cell turnover was observed in MMP-7 deficient mice.
  • Increased inflammation, proliferation, and apoptosis were not dependent on MMP-7 for bacterial clearance.

Conclusions:

  • H. pylori-induced MMP-7 expression may protect the gastric mucosa.
  • MMP-7 deficiency exacerbates gastritis and associated pathophysiological processes.
  • These findings suggest MMP-7 plays a protective role against H. pylori-driven carcinogenesis.

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