Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Assessment of the Cardiovascular System III: Palpation01:27

Assessment of the Cardiovascular System III: Palpation

Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above the...
Cardiovascular System Abnormal Findings I: Inspection and Palpation01:29

Cardiovascular System Abnormal Findings I: Inspection and Palpation

In a cardiovascular examination, inspection and palpation are crucial for identifying abnormalities.
Abnormal findings observed during an inspection
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cross-sectional association of endogenous steroid hormone, sex hormone-binding globulin, and precursor steroid levels with hemostatic factor levels in postmenopausal women.

Journal of thrombosis and haemostasis : JTH·2016
Same author

Causes of venous thrombosis.

Thrombosis journal·2016
Same author

The transcendental scientist.

Journal of thrombosis and haemostasis : JTH·2016
Same author

Going abroad.

Journal of thrombosis and haemostasis : JTH·2016
Same author

The p-value: A clinician's disease?

European journal of internal medicine·2016
Same author

No P Please.

Journal of thrombosis and haemostasis : JTH·2016

Related Experiment Video

Updated: Jun 17, 2026

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model
08:16

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model

Published on: March 16, 2022

Coagulation abnormalities in Legg-Calvé-Perthes disease.

A Vosmaer1, R Rodrigues Pereira, J S Koenderman

  • 1Department of Orthopaedics, Ikazia Hospital, P.O. Box 5009, 3008 AA Rotterdam, the Netherlands. a.vosmaer@ikazia.nl

The Journal of Bone and Joint Surgery. American Volume
|January 6, 2010
PubMed
Summary

Thrombophilia, or a tendency to clot, is linked to Legg-Calvé-Perthes disease in children. Specific genetic mutations and protein levels increase the risk, particularly in males, suggesting a thrombotic component in its cause.

More Related Videos

In Vitro Thrombosis Test for Ventricular Assist Devices
09:15

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock
06:10

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Published on: June 12, 2021

Related Experiment Videos

Last Updated: Jun 17, 2026

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model
08:16

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model

Published on: March 16, 2022

In Vitro Thrombosis Test for Ventricular Assist Devices
09:15

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock
06:10

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Published on: June 12, 2021

Area of Science:

  • Pediatric Orthopedics
  • Hematology
  • Genetics

Background:

  • Legg-Calvé-Perthes disease involves osteonecrosis of the proximal femoral epiphysis in children.
  • The exact cause is unknown, but vascular occlusions and hypercoagulable disorders are suspected.
  • This study investigates the role of thrombophilia in the etiology of Legg-Calvé-Perthes disease.

Purpose of the Study:

  • To evaluate the etiologic role of thrombophilia in pediatric Legg-Calvé-Perthes disease.
  • To determine the association between specific thrombophilic factors and the risk of developing the condition.

Main Methods:

  • A case-control study involving 169 pediatric patients diagnosed with Legg-Calvé-Perthes disease.
  • Inclusion of two control groups: 474 subjects from a venous thrombosis study and 38 children treated for asthma.
  • Analysis of protein C, protein S, factor VIII, fibrinogen levels, and factor V Leiden and prothrombin G20210A mutations.

Main Results:

  • Increased risk of Legg-Calvé-Perthes disease associated with factor V Leiden mutation (OR, 3.3), prothrombin G20210A mutation (OR, 2.6), elevated factor VIII (OR, 7.5), and protein S deficiency (OR, 2.8).
  • No significant association found between high fibrinogen or protein C deficiency and the disease.
  • Males exhibited a higher risk (OR, 2.4) and stronger effects of certain thrombophilic factors, with risk increasing with more coagulation abnormalities.

Conclusions:

  • The findings suggest a significant thrombotic component in the etiology of Legg-Calvé-Perthes disease.
  • Specific thrombophilic factors contribute to the risk, especially in males.
  • Further research into coagulation disorders is warranted for understanding and potentially managing the disease.