Related Experiment Video
Updated: Jun 17, 2026

Isolation of Human Atrial Myocytes for Simultaneous Measurements of Ca2+ Transients and Membrane Currents
Published on: July 3, 2013
[Calcium antagonists: current and future applications based on new evidence. Calcium channel blockers in the elderly
Mitsuru Ohishi1, Hiromi Rakugi
1Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
Abstract:
As calcium channel blocker (CCB) shows high level of tolerance, blood pressure lowering effect and organ blood flow, we usefully use to manage the elderly hypertensives, and the guideline by Japanese Society of Hypertension in 2009 reveals as a first line drug. Although there is a few multi-center study about the elderly hypertensives, Syst-Eur, NICS-EH, STOP Hypertension-2, PATE-Hypertension, CASE-J showed CCB could prevent the occurrence of cerebro-cardiovascular events. CCB also prevents cerebro-cardiovascular events in the elderly hypertensives with diabetes. Accumulating these evidences, CCB is very useful for treatment of elderly hypertensive patients not only as a first-line drug, but also a second or third-line drug.
Related Concept Videos
Antihypertensive Drugs: Action of Calcium Channel Blockers
Antianginal Drugs: Calcium Channel Blockers and Ranolazine
CCBs, a diverse class that includes dihydropyridines (nifedipine) and diphenylalkylamines (verapamil and diltiazem), exert their effect by blocking calcium channels in cardiac and smooth muscle cells. This...
Antiarrhythmic Drugs: Class IV Agents as Calcium Channel Blockers
Verapamil, a calcium channel blocker, inhibits calcium movement across myocardial cell membranes and vascular smooth muscle. This results in the dilation of coronary and...
Antiepileptic Drugs: Calcium Channel Blockers
Calcium channel blockers exert their antiepileptic effects by targeting T-type calcium channels, which are integral to transmitting nerve signals in the central nervous system. These channels allow the passage of calcium ions, which are vital for neuronal communication. By inhibiting T-type calcium channels, calcium channel blockers effectively reduce the release of neurotransmitters and...
Antiarrhythmic Drugs: Class I Agents as Sodium Channel Blockers
Class 1A Antiarrhythmic Drugs: These drugs work by moderately blocking sodium channels,...
Adrenergic Antagonists: ɑ and β-Receptor Blockers