Related Experiment Video
Updated: Jun 17, 2026

Optocardiography and Electrophysiology Studies of Ex Vivo Langendorff-perfused Hearts
Published on: November 7, 2019
Simple method of counterclockwise isthmus conduction block by comparing double potentials and flutter cycle length
Kyoung-Suk Rhee1, Keun-Sang Kwon, Sun Hwa Lee
1Division of Cardiology, Department of Internal Medicine, Research Institute of Clinical Medicine, Chonbuk National University, Jeonju, Korea.
Assessing cavotricuspid isthmus ablation for atrial flutter requires confirming conduction block. A combined electrogram interval (SD1+SD2) near the flutter cycle length accurately predicts block, ensuring effective treatment.
Area of Science:
- Electrophysiology
- Cardiac Ablation
- Atrial Flutter Management
Background:
- Cavotricuspid isthmus (CTI) ablation is key for isthmus-dependent atrial flutter.
- Distinguishing complete block from slow conduction post-ablation can be challenging.
- Flutter cycle length (FCL) reflects tricuspid annulus conduction time, useful for block confirmation.
Purpose of the Study:
- To determine the electrogram splitting degree needed to confirm complete CTI block.
- To use FCL as a reference for assessing conduction block accuracy.
Main Methods:
- Fifty patients undergoing CTI ablation were studied.
- Measured intervals: SD1 (counterclockwise conduction time) and SD2 (clockwise conduction time).
- SD1 and SD2 were recorded before and after ablation to assess block.
Main Results:
- An SD1+SD2 interval reaching 90% of the FCL accurately identified counterclockwise conduction block.
- This criterion demonstrated 94% sensitivity and 100% specificity.
Conclusions:
- A sum of SD1 and SD2 close to the FCL reliably predicts complete isthmus conduction block.
- This method offers high diagnostic accuracy and positive predictive value for counterclockwise conduction block.
Related Concept Videos
Dysrhythmias IV: Characteristics of Bradyarrhythmias
Electrophysiology of Normal Cardiac Rhythm
Cardiac Action Potential
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
Disturbances in Heart Rhythm
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
Correlation between ECG and Cardiac Cycle
A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...
Conduction System of the Heart
The pacemaker cells are located in two primary nodes: the sinoatrial (SA) node and the atrioventricular (AV) node. The SA node pacemaker cells can autonomously depolarize, triggering an action potential that leads to the...

