Related Experiment Video For atherosclerosis
Updated: Jun 17, 2026

Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice
Published on: January 13, 2012
Chronic stress and the development of early atherosclerosis: moderating effect of endothelial dysfunction and
Nadja Chumaeva1, Mirka Hintsanen, Niklas Ravaja
1Department of Psychology, University of Helsinki, Helsinki, Finland. nadezda.chumaeva@helsinki.fi
Abstract:
This study aims to explore the interactive effect of vital exhaustion (VE) and endothelial dysfunction on preclinical atherosclerosis, assessed by carotid intima-media thickness (IMT). Furthermore, interaction between VE and carotid elasticity is examined. Participants were 1,596 young healthy adults from the Cardiovascular Risk in Young Finns study. Endothelial dysfunction was measured by brachial flow-mediated dilatation (FMD), and carotid elasticity by carotid artery compliance (CAC). Significant interactions between FMD and VE, and between CAC and VE, for IMT were found in participants with the very lowest FMD and CAC. Thus, VE may be harmful if the endothelium is not working properly.
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