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Updated: Jun 17, 2026
Absolute Quantification of Aβ1-42 in CSF Using a Mass Spectrometric Reference Measurement Procedure
Published on: March 21, 2017
A surrogate marker for Abeta42 production in the CNS
1Department of Neurology, Developmental Biology, Hope Center for Neurological Disorders, and the Alzheimer's Disease Research Center, Washington University, St. Louis, MO 63110, USA. holtzman@neuro.wustl.edu
Abstract:
Alzheimer's disease (AD) is the most common cause of dementia. There are currently no effective treatments that may delay the onset, slow the progression or prevent the disease. Unless such treatments are developed, the number of AD cases is expected to double in the next 30 years. There is overwhelming genetic and biochemical evidence that the aggregation and buildup of the amyloid-beta (Abeta) peptide plays a critical role in AD pathogenesis.
