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Related Experiment Video

Updated: Dec 11, 2025

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes
09:51

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes

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Radioactive liposomes.

William Thomas Phillips1, Beth Ann Goins1, Ande Bao1

  • 1Radiology Department, University of Texas Health Science Center at San Antonio, TX, USA.

Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
|January 6, 2010
PubMed
Summary

Liposomes can be labeled with radionuclides for diagnostic imaging and cancer therapy. This review covers methods for tracking liposomes using SPECT and PET imaging and their therapeutic applications.

Area of Science:

  • Nanomedicine
  • Radiochemistry
  • Nuclear Medicine

Background:

  • Liposomes have been studied for 40 years.
  • Methods for labeling liposomes with diagnostic and therapeutic radionuclides have been developed.
  • Diagnostic radiolabels enable quantitative tracking of nanometer-sized liposomes in vivo.

Purpose of the Study:

  • To review methods for labeling liposomes with radionuclides for diagnostic imaging and therapeutic applications.
  • To highlight the use of single photon emission computed tomography (SPECT) and positron emission tomography (PET) for liposome tracking.
  • To discuss recent advancements in using radiolabeled liposomes for cancer therapy.

Main Methods:

  • Review of single photon emission computed tomography (SPECT) and positron emission tomography (PET) imaging techniques.

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  • Discussion of methods for labeling liposomes with single photon and dual photon positron emission radionuclides.
  • Presentation of examples of diagnostic imaging agents and therapeutic applications.

    • Main Results:

    • Diagnostic radiolabels allow quantitative tracking of liposome uptake in humans and animals.
    • Tracking liposome distribution aids in developing liposome-based drug delivery systems.
    • Therapeutic radionuclides attached to liposomes show promise for cancer treatment.

    Conclusions:

    • Radiolabeling and tracking technologies for liposomes are valuable tools in nanomedicine.
    • Liposome-based diagnostic imaging and therapeutic strategies are advancing.
    • These technologies are applicable to other nanoparticles beyond liposomes.