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Oral Drug Delivery Systems: Delayed-Release Systems01:11

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Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
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Related Experiment Video

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Fabrication of Small Caliber Stent-grafts Using Electrospinning and Balloon Expandable Bare Metal Stents
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Drug-eluting stent coatings.

Judit E Puskas1, Lyn G Muñoz-Robledo, Robert A Hoerr

  • 1The University of Akron, Akron, OH 44325-3909, USA. jpuskas@uakron.edu

Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
|January 6, 2010
PubMed
Summary

Researchers developed new drug-eluting coronary stent coatings using dendritic polyisobutylene (D_SIBS) polymers. These novel coatings, applied via electro-nanospray, showed tunable drug release profiles influenced by polymer structure and processing.

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Area of Science:

  • Polymer Science
  • Biomaterials Engineering
  • Cardiovascular Device Technology

Background:

  • Poly(styrene-b-isobutylene-b-styrene) block copolymer (SIBS) is a clinically used nanostructured thermoplastic elastomer for drug-eluting coronary stent coatings.
  • Development of novel stent systems requires interdisciplinary approaches focusing on advanced polymer architectures.

Purpose of the Study:

  • To review coronary stent development from a polymer science perspective.
  • To present initial findings on new stent systems utilizing arborescent (dendritic) polyisobutylene cores (D_SIBS).
  • To investigate the influence of D_SIBS polymer characteristics and electro-nanospray conditions on drug release profiles.

Main Methods:

  • Synthesis and characterization of arborescent polyisobutylene (D_SIBS) architectures.
  • Coating of coronary stents and test coupons using ElectroNanospray with D_SIBS polymers loaded with dexamethasone.
  • Analysis of surface topology and drug release kinetics.

Main Results:

  • D_SIBS polymers demonstrated biocompatibility comparable to clinical SIBS.
  • Electro-nanospray resulted in varied surface topographies, from smooth to nanosized particulate coatings.
  • Drug release profiles were significantly influenced by the molecular weight of the polyisobutylene core and electro-nanospray parameters.

Conclusions:

  • Arborescent polyisobutylene (D_SIBS) represents a promising biomaterial for advanced drug-eluting coronary stent coatings.
  • Electro-nanospray is an effective technique for creating tunable D_SIBS coatings with controlled drug release.
  • Further development of D_SIBS-based stent systems holds potential for improved cardiovascular therapies.