Early decompressive hemicraniectomy in fulminant herpes simplex encephalitis
N Maraite1, F Mataigne, V Pieri
1Department of Neurosciences, Centre Hospitalier de Luxembourg, Luxembourg-City, Luxembourg.
Summary
Herpes encephalitis can be fatal, but decompressive hemicraniectomy can improve outcomes in severe cases. This procedure helped a patient with brain swelling achieve a satisfactory long-term recovery.
Area of Science:
- Neurology
- Neurosurgery
Background:
- Herpes encephalitis is a severe neurological condition often requiring prompt treatment with acyclovir.
- Rapidly progressive cerebral edema can lead to poor outcomes despite antiviral therapy.
Observation:
- A 66-year-old patient presented with herpes encephalitis, a Glasgow Coma Score (GCS) of 6, and signs of uncal herniation.
- The patient developed incipient uncus herniation of the right temporal lobe on the third day of illness.
Findings:
- Decompressive hemicraniectomy was performed emergently to address the critical brain swelling.
- The patient experienced a satisfactory long-term outcome, regaining unassisted gait and achieving a Barthel Index score of 70 after 9 months.
Implications:
- Decompressive hemicraniectomy is a potentially life-saving intervention for herpes encephalitis with severe cerebral edema and herniation.
- Early surgical intervention can significantly improve neurological function and quality of life in patients with severe herpes encephalitis.
Related Concept Videos
Encephalitis l: Introduction
Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
Encephalitis ll: Pathophysiology
Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
Brain Abscess l: Introduction
A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
Cryptococcal Meningitis
Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Cerebral Edema ll: Pathophysiology
Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...

