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Updated: Jun 17, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Synthesis of triazolothiazolidinone derivatives of coumarin with antimicrobial activity
Mashooq A Bhat1, Nadeem Siddiqui, Suroor A Khan
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Khartoum College of Medical Science, Aljerief West, 1st Block Number 398, P.O. Box 10995, Khartoum, Sudan. mashooqbhat@rediffmail.com
Abstract:
A series of 2-(substituted phenyl)-3-[3-(2-oxo-2H-chromen-3-yl)-5-thioxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]-1,3-thiazolidin-4-ones, 8a-n, were synthesized and evaluated for their antimicrobial activity. The structures of the compounds were confirmed on the basis of their elemental analysis and spectral data. Compounds 8k, 81 and 8m showed significant inhibition against S. aureus, compound 8m showed significant inhibition against E. coli and compounds 8b, 8e, 8i, 8j, 8k, 81 and 8m showed significant inhibition against C. albicans.
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