Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene01:13

Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene

Bromination and chlorination of aromatic rings by electrophilic aromatic substitution reactions are easily achieved, but fluorination and iodination are difficult to achieve. Fluorine is so reactive that its reaction with benzene is difficult to control, resulting in poor yields of monofluoroaromatic products. To address this, Selectfluor reagent is used as a fluorine source in which a fluorine atom is bonded to a positively charged nitrogen.
Ion-Exchange Chromatography01:09

Ion-Exchange Chromatography

Ion-exchange chromatography, or IEC, is a technique for separating ions based on their affinity for the stationary phase. The stationary phase is a cross-linked polymer resin with covalently attached ionic functional groups. The functional groups can be either positively charged (cation exchangers) or negatively charged (anion exchangers). A cation exchanger consists of a polymeric anion and active cations, while an anion exchanger is a polymeric cation with active anions. The choice of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Electrolyte-anion-controlled reactivity of aromatic radical cations.

Chemical science·2026
Same author

Precisely Controlled Electrochemical Phosphonylation: Tailoring π-Conjugated Polymer Properties for High-Performance Organic Electrochemical Transistors.

Angewandte Chemie (International ed. in English)·2026
Same author

Electrochemical Postmodification of Polystyrene via Aromatic C-H Iodination.

ACS macro letters·2025
Same author

An electrochemiluminescence device powered by streaming potential for the detection of amines in flowing solution.

Nature communications·2025
Same author

Organophotoredox-Catalyzed Postfunctionalization of Poly(methacrylate) Derivatives via Radical-Polar Crossover Phosphonylation.

Angewandte Chemie (International ed. in English)·2025
Same author

Orthogonal Synthesis of Cationic Azatriphenylene Derivatives for Aggregation-Induced Emission (AIE) and Aggregation-Caused Quenching (ACQ) Property Switching.

Organic letters·2025

Related Experiment Video

Updated: Jun 17, 2026

Synthesis of Ionic Liquid Based Electrolytes, Assembly of Li-ion Batteries, and Measurements of Performance at High Temperature
11:04

Synthesis of Ionic Liquid Based Electrolytes, Assembly of Li-ion Batteries, and Measurements of Performance at High Temperature

Published on: December 20, 2016

Use of task-specific ionic liquid for selective electrocatalytic fluorination.

Takahiro Sawamura1, Shunsuke Kuribayashi, Shinsuke Inagi

  • 1Department of Electronic Chemistry, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8502, Japan.

Organic Letters
|January 7, 2010
PubMed
Summary
This summary is machine-generated.

Researchers achieved highly selective indirect anodic fluorination of organic compounds for the first time. This breakthrough utilized a novel task-specific ionic liquid (iodoarene) mediator in ionic liquid hydrogen fluoride salts.

More Related Videos

In Situ Lithiated Reference Electrode: Four Electrode Design for In-operando Impedance Spectroscopy
09:36

In Situ Lithiated Reference Electrode: Four Electrode Design for In-operando Impedance Spectroscopy

Published on: September 12, 2018

From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding
06:44

From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding

Published on: March 24, 2018

Related Experiment Videos

Last Updated: Jun 17, 2026

Synthesis of Ionic Liquid Based Electrolytes, Assembly of Li-ion Batteries, and Measurements of Performance at High Temperature
11:04

Synthesis of Ionic Liquid Based Electrolytes, Assembly of Li-ion Batteries, and Measurements of Performance at High Temperature

Published on: December 20, 2016

In Situ Lithiated Reference Electrode: Four Electrode Design for In-operando Impedance Spectroscopy
09:36

In Situ Lithiated Reference Electrode: Four Electrode Design for In-operando Impedance Spectroscopy

Published on: September 12, 2018

From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding
06:44

From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding

Published on: March 24, 2018

Area of Science:

  • Organic Chemistry
  • Electrochemistry
  • Fluorination Chemistry

Background:

  • Selective fluorination of organic compounds is crucial for synthesizing pharmaceuticals and materials.
  • Traditional fluorination methods often lack selectivity or require harsh conditions.
  • Developing novel, efficient, and selective fluorination techniques remains a significant challenge in organic synthesis.

Purpose of the Study:

  • To develop a highly selective method for indirect anodic fluorination of organic compounds.
  • To explore the use of task-specific ionic liquids as mediators in electrochemical fluorination.
  • To establish a novel synthetic route for introducing fluorine into organic molecules.

Main Methods:

  • Electrochemical fluorination using a divided cell.
  • Employing a task-specific ionic liquid containing an iodoarene moiety as a mediator.
  • Utilizing ionic liquid hydrogen fluoride salts as the fluoride source and electrolyte.

Main Results:

  • Achieved highly selective indirect anodic fluorination of various organic compounds for the first time.
  • Demonstrated the effectiveness of the iodoarene-based ionic liquid as a mediator in promoting selectivity.
  • The developed method offers a novel and efficient approach to C-F bond formation.

Conclusions:

  • The study successfully established a novel and highly selective method for indirect anodic fluorination.
  • Task-specific ionic liquids are effective mediators for electrochemical fluorination reactions.
  • This work provides a valuable new tool for the synthesis of fluorinated organic compounds.