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Multiple endocrine neoplasia-2B presenting with orthodontic relapse
Brent Accurso1, Ana Mercado, Carl M Allen
1The Ohio State University, Columbus, 43210, USA. brent.accurso@gmail.com
The Angle Orthodontist
|January 7, 2010
Summary
Multiple Endocrine Neoplasia type 2B (MEN-2B) presents early oral signs. Dental professionals can aid early diagnosis of this rare genetic disorder, crucial for preventing thyroid cancer.
Area of Science:
- Endocrinology
- Genetics
- Oral Pathology
Background:
- Multiple Endocrine Neoplasia (MEN) syndromes are rare genetic disorders affecting endocrine organs.
- MEN type 2B (MEN-2B) is notable for early oral manifestations, often preceding other symptoms.
- Early diagnosis of MEN-2B is critical due to the high risk of early-onset medullary thyroid carcinoma.
Observation:
- A 17-year-old male presented with oral abnormalities.
- These abnormalities prompted an oral and maxillofacial pathology consultation.
- The consultation was initiated by the patient's orthodontist.
Findings:
- The patient's oral manifestations were indicative of MEN-2B.
- The orthodontist's referral led to the initial diagnosis of MEN-2B.
- Early identification of MEN-2B was facilitated by dental examination.
Implications:
- Dental professionals play a key role in the early detection of MEN-2B.
- Prompt diagnosis allows for timely management of associated malignancies, particularly medullary thyroid carcinoma.
- Recognizing oral signs of MEN-2B can significantly improve patient outcomes and prognosis.
