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A fluoxetine-induced frontal lobe syndrome in an obsessive compulsive patient
R Hoehn-Saric1, G J Harris, G D Pearlson
1Johns Hopkins Medical Institutions Department of Psychiatry and Behavioral Sciences, Baltimore, MD 21205.
The Journal of Clinical Psychiatry
|March 1, 1991
Abstract:
The authors report the occurrence of apathy, indifference, inattention, and perseveration in an obsessive compulsive patient taking high doses of fluoxetine. These changes were associated with a decrease in cerebral blood flow in the frontal lobes and changes in neuropsychological tests generally associated with frontal lobe impairment. These clinical manifestations disappeared 4 weeks after discontinuation of fluoxetine.