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Updated: Jun 17, 2026

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
05:53

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates

Published on: July 6, 2013

Management of congenital cytomegalovirus infection: an evidence-based approach

R S Gandhi1, J R Fernandez-Alvarez, H Rabe

  • 1Department of Neonatology, Brighton and Sussex University Hospitals NHS Trust, Brighton, UK. rashmiajmera@doctors.net.uk

Acta Paediatrica (Oslo, Norway : 1992)
|January 7, 2010
PubMed

Insights

Congenital cytomegalovirus (CMV) is a common infection causing developmental issues. This review provides an algorithm for early identification and management of infected newborns, improving outcomes.

Area of Science:

  • Neonatology
  • Infectious Diseases
  • Public Health

Background:

  • Congenital cytomegalovirus (CMV) is the most frequent congenital infection.
  • It is a leading cause of non-genetic sensorineural hearing loss and psychomotor impairment in children.
  • Knowledge gaps exist regarding the early identification and management of affected neonates.

Purpose of the Study:

  • To review the current literature on congenital CMV.
  • To develop a practical algorithm for the identification and management of neonates with congenital CMV.

Main Methods:

  • A comprehensive literature review was conducted.
  • An evidence-based algorithm was devised for clinical application.

Main Results:

  • The review synthesizes current understanding of congenital CMV.
  • The proposed algorithm outlines steps for diagnosis and initial management.
  • Early identification and management strategies are crucial for mitigating long-term sequelae.

Conclusions:

  • Applying current knowledge to manage congenital CMV neonates is beneficial.
  • Further research is needed to refine diagnostic and therapeutic approaches.
  • The developed algorithm serves as a guide pending more extensive evidence.
Abstract

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