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Related Experiment Video

Updated: Jun 17, 2026

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
05:16

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

Published on: August 4, 2021

Placental thrombomodulin expression in recurrent miscarriage.

Piergiorgio Stortoni1, Monia Cecati, Stefano R Giannubilo

  • 1Department of Clinical Sciences, Polytechnic University of Marche, Ancona, Italy.

Reproductive Biology and Endocrinology : RB&E
|January 7, 2010
PubMed
Summary

Reduced thrombomodulin expression in placental tissue is linked to spontaneous recurrent miscarriage. This finding suggests a potential role for thrombomodulin in early pregnancy loss, warranting further investigation into its biological pathways.

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Area of Science:

  • Reproductive Biology
  • Vascular Biology
  • Obstetrics

Background:

  • Early pregnancy loss is associated with trophoblast insufficiency and coagulation defects.
  • Thrombomodulin (TM) is an endothelial anticoagulant protein crucial for hemostasis and inflammation.
  • TM acts as a cofactor in the protein C anticoagulant pathway.

Purpose of the Study:

  • To evaluate thrombomodulin expression in placental tissue.
  • To compare expression levels between spontaneous recurrent miscarriage and control groups.

Main Methods:

  • Quantitative real-time polymerase chain reaction (qPCR) was used to determine thrombomodulin mRNA levels.
  • Placental tissue samples were collected from women with spontaneous recurrent miscarriage and voluntary abortions (controls).

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Published on: January 26, 2024

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Last Updated: Jun 17, 2026

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
05:16

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

Published on: August 4, 2021

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
05:31

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Published on: January 26, 2024

Main Results:

  • A significant reduction in thrombomodulin expression was observed in the recurrent miscarriage group compared to controls.
  • Thrombomodulin mRNA levels were reduced by 1.82-fold, corresponding to a 45% decrease in expression.

Conclusions:

  • Reduced placental thrombomodulin expression may be associated with spontaneous recurrent miscarriage.
  • Further research is required to elucidate the precise role of thrombomodulin in trophoblast physiology and reproductive health.